Tackling the Renal Continuum: New Data, New Prospects

Monday 23rd April 2007

Tackling the Renal Continuum: New Data, New Prospects

Rio de Janeiro, Brazil

We welcome you to this webcast, which presents the symposium - Tackling the Renal Continuum: New Data, New Prospects - recorded at The World Congress of Nephrology, 2007.

An early stage of the renal continuum is endothelial dysfunction, characterized by impaired nitric oxide activity, the initiation of atherosclerotic disease and associated vascular remodelling within the kidneys. Without effective renoprotection, incipient nephropathy, which manifests as microalbuminuria, develops. This is followed by overt nephropathy with macroalbuminuria and a decline in the glomerular filtration rate. Eventually, end-stage renal disease, requiring haemodialysis or renal replacement therapy to ensure patient survival, will occur. At each stage of the renal continuum, the risk of cardiovascular events is also increased.

Targeting the renin-angiotensin system using an angiotensin II receptor blocker (ARB) not only controls blood pressure, but also protects against the detrimental effects of angiotensin II within the kidneys and the cardiovascular system.

The ONgoing Telmisartan Alone in combination with Ramipril Global Endpoint Trial (ONTARGET) will provide important information on the ability of the combination of ARB telmisartan and the ACE inhibitor ramipril to enhance cardio- and renal protection beyond blood pressure control in patients at high risk.

Faculty

Symposium Chairmen

• Artur Beltrame Ribeiro - Nephrology Division UNIFESPEPM Hospital do Rim e Hipertensó, Sáo Paulo, Brazil
• Dick de Zeeuw - Department of Clinical Pharmacology, Groningen, The Netherlands

Speakers

• Roland Schmieder - Department of Nephrology and Hypertension Friedrich Alexander University, Erlangen-Nürnberg, Germany
• George Bakris - Department of Preventive Medicine Rush University Center, Illinois, USA
• Steve Bain - Diabetes and Endocrine Unit Swansea NHS Trust, Swansea, UK

Agenda

• Welcome and opening remarks - Artur Beltrame Ribeiro, Brazil
• Introduction - Dick de Zeeuw, The Netherlands
• Current concepts in the pathophysiology of early diabetic nephropathy - Roland Schmieder, Germany
• Halting the progression of manifest renal disease - Steve Bain, UK
• Reducing proteinuria: future clinical possibilities and potential benefits - George Bakris, USA
• Conclusion - Dick de Zeeuw, The Netherlands

To start the webcast, please click on the link below. You will then be able to read an overview, the agenda, or the presentation abstracts for each symposium, as well as view the presentations. The agenda and program overview for each symposium are also presented below.

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